1 Thessalonians 2:15
Who both killed the Lord Jesus, and their own prophets, and have persecuted us; and they please not God, and are contrary to all men:
Note 6 at 1Th 2:15: It is sad that unbelief not only causes people to perish, but often those who reject the Gospel endeavor to hinder others from receiving God's Truth as well. That's what the unbelieving Jews did. They not only rejected the message of God's true prophets, but they killed them so others would not be influenced.
The American Heritage Dictionary says that to "respond" means "1. To make a reply; answer. 2. To act in return or in answer." When Christ is preached, it produces a response but not always a positive one. Everywhere Paul went, there was either a revival or a riot, but never indifference (see note 2 at Ac 14:4).