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Acts 14:6

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They were ware of [it], and fled unto Lystra and Derbe, cities of Lycaonia, and unto the region that lieth round about:

Note 4 at Ac 14:6: Lystra was a small city in Lycaonia (see note 6 at this verse), a Roman colony of Asia Minor. On this first visit to Lystra by Paul, the Lord healed a man who had been crippled from birth (Ac 14:8-10). The people of the city would have done sacrifices to Paul and Barnabas if they had not restrained them (Ac 14:11-18). These same people who wanted to worship the apostles later stoned them and left them for dead (Ac 14:19-20).

It was either at Lystra or Derbe that Paul met Timothy on his second missionary journey (Ac 16:1-2).

Paul passed through this area on all three of his missionary trips. Lystra was approximately twenty miles south-southwest of Iconium (see note 3 at Ac 13:51) and twenty (or fifty) miles west-northwest of Derbe (see note 5 at this verse).

Note 5 at Ac 14:6: Derbe was a city in the southeastern part of the Roman province of Lycaonia (see note 6 at this verse) located in Asia Minor. The exact location of Derbe has recently been disputed since an inscription was found about thirty miles east of what was commonly thought to be the city's site. Therefore, Derbe was either twenty or fifty miles away from Lystra.

Paul went through Derbe on all three of his missionary trips. Gaius, who became a companion of Paul, was from Derbe (Ac 20:4).

Note 6 at Ac 14:6: Lycaonia was a small Roman province of Asia Minor, bordered on the north by Galatia, the east by Cappadocia (see note 15 at Ac 2:9), on the south by Cilicia (see note 5 at Ac 6:9), and on the west by Pisidia and Phrygia. Its principal towns were Iconium (see note 3 at Ac 13:51), Lystra (see note 4 at this verse), and Derbe (see note 5 at this verse). The people of this region spoke a peculiar dialect--a corrupted Greek mingled with Syrian. This is what Ac 14:11 refers to when it mentions "the speech of Lycaonia."