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Matthew 16

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Matthew 16:12
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Matthew 16:12
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Then understood they how that he bade [them] not beware of the leaven of bread, but of the doctrine of the Pharisees and of the Sadducees.

Note 2 at Mt. 16:12: Because of their hardened heart, these disciples thought of only the physical meaning of the word "leaven." However, just as in Jesus' reply to the multitude in John 6:22-71, the words that Jesus was speaking were spirit and life (Jn. 6:63). He was not speaking of yeast but of the doctrine of the Pharisees, which was hypocrisy (Lk. 12:1).